Cell based assays - Physiologically relevant measurements
Eliminating the need to generate recombinant cell lines utilizing artificial reporters of cell signaling events reduces assay development time and increases the likelihood of selecting physiologically relevant hits in your screening process. With BIND, assessment of the quality of cells is incorporated into every assay measurement ensuring only the best data is obtained. BIND kinetic data provides both a quantitative measurement of a compound’s effect as well as temporal data that is useful in clustering compound activity based on mechanism.
- Unique label-free cell-based applications for measurement of G-protein coupled receptors, receptor tyrosine kinases and ion channels
- Measurement of cell health improves screening success
- Robust measurement of endogenous receptors
- Information rich data uncovering signaling mechanism and drug mode of action
The kinetic data obtained provides both a quantitative measurement of endogenous target response to stimulation
or inhibition as well as additional information qualifying the signal transduction pathway. G-Protein coupled
receptors demonstrate characteristic temporal response due to mechanism of signal coupling to Gs, Gq or Gi.